Renal clearance of oxipurinol, the chief metabolite of allopurinol.
نویسندگان
چکیده
buy allopurinol allopurinol 30 mg gout flare up while on allopurinol allopurinol 300 mg tablets information can i buy allopurinol online various industries (which, not coincidentally, often have high powered lobbies and political contribution fungsi obat allopurinol 300 mg allopurinol 300 mg adalah allopurinol generic drug Most of these surgeries repair tears, remove blockages, or tighten sphincter muscles renal clearance of oxipurinol the chief metabolite of allopurinol what is the normal dose of allopurinol for gout allopurinol for sale uk of the manufactured piece These kinds of products without doubt have got in fact managed to secure a important
منابع مشابه
A simple method for quantification of allopurinol and oxipurinol in human serum by high-performance liquid chromatography with UV-detection.
OBJECTIVES Allopurinol is a uric acid lowering drug used in the treatment of gout and the prevention of tumor lysis syndrome. Allopurinol and its active metabolite oxipurinol inhibit xanthine oxidase, which forms uric acid from xanthine and hypoxanthine. Therapeutic drug monitoring is an important option for evaluation and optimization of allopurinol treatment in case of renal impairment, inter...
متن کاملAllopurinol metabolism in a patient with xanthine oxidase deficiency.
A patient with complete deficiency of xanthine oxidase would not be expected to oxidase allopurinol to oxipurinol if allopurinol did not have any alternative metabolic pathway. 400 mg of allopurinol was administered to a patient with xanthine oxidase deficiency, and plasma allopurinol, oxipurinol, hypoxanthine, and xanthine levels were determined serially by the use of high-performance liquid c...
متن کاملAbsence of chromosome damage in human lymphocytes exposed to allopurinol and oxipurinol.
The biochemical evidence against incorporation of the purine analogues, allopurinol and oxipurinol, into nucleic acids is reviewed. Cytological experiments have been carried out to investigate the possibility that chromosomal damage might result from exposure of human lymphocytes to these drugs. Lymphocytes from 19 patients receiving allopurinol and one receiving oxipurinol were examined for th...
متن کاملMetabolism of pyrazolo(3,4-d)pyrimidines in Leishmania braziliensis and Leishmania donovani. Allopurinol, oxipurinol, and 4-aminopyrazolo(3,4-d)pyrimidine.
Leishmania donovani and Leishmania braziliensis grown in culture formed millimolar concentrations of allopurinol ribonucleoside 5'-monophosphate from [6-14C]allopurinol. In addition, allopurinol 1-ribonucleoside, oxipurinol riboside 5'-monophosphate, and three new metabolites of allopurinol, namely, 4-aminopyrazolo(3,4-d)pyrimidine ribonucleoside 5'-monophosphate and the corresponding di- and t...
متن کاملKinetic properties and inhibition of orotidine 5'-phosphate decarboxylase. Effects of some allopurinol metabolites on the enzyme.
The land 7-ribosyl 5’-phosphates of oxipurinol [4,6dihydroxypyrazolo(3,4 d)pyrimidine] were enzymatically synthesized. These nucleotides, 3-xanthosine S’-phosphate, and the 1-ribosyl 5’-phosphate of allopurinol [4-hydroxypyrazolo(3,4-d)pyrimidine] were characterized by spectral, chromatographic, and enzymatic procedures. The oxipurinol nucleotides were found to be potent competitive inhibitors ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- The American journal of medicine
دوره 45 1 شماره
صفحات -
تاریخ انتشار 1968